Mark Tartulli's humor is definitely outside the box -- literally. His innovative comic strip Lio often plays with the confines of the comic strip panels, breaking through them and other wise incorporating them into the story (see Lio and the Fourth Wall for other examples). In his 3/14/14 strip, Lio's in a perilous place. (click on image to enlarge).
One more thing -- note how all the normal details of Tartulli's strip reinforce our perception that Lio exists on the surface of the paper. The signature, date, copyright notice and web address are all tumbling down the page.
Another comic tour-de-force by Tartulli.