The nice thing about the Sunday comics is that artists have a bigger space to play with (well, relatively bigger). Jef Mallet used the allotted area quite creatively in the March 15, 2015 sequence of his strip Frazz.
Here's the strip as it appeared. (click on image to enlarge)
Notice what Mallet did? Normally a Sunday section will have two rows of 3 or 4 panels that are read sequentially; top row left to right, then bottom row left to right. In this case, the top and bottom rows are united, showing two events that are occurring simultaneously in to specific locations; Mrs. Olsen's desk and Caulfield's desk.
In essence, the strip should be read like this:
Notice that the final panel uses the full space to unite the two threads into a conclusion with the punch line.